Tokyo :  Eisai Co., Ltd. announced today that five oral presentations including a symposium, and two poster presentations, highlighting the latest data on its Alzheimer’s disease / dementia pipeline including anti-amyloid beta (Abeta) protofibril antibody BAN2401, oral beta secretase cleaving enzyme (BACE) inhibitor elenbecestat, anti-Abeta antibody aducanumab, and dual orexin receptor antagonist lemborexant, will be given at the 11th Clinical Trials on Alzheimer’s Disease (CTAD) conference taking place in Barcelona, Spain, from October 24 to 27. BAN2401, elenbecestat and aducanumab are being jointly developed by Eisai and Biogen Inc.

For BAN2401, a one-hour presentation will be given as a symposium to provide clinical and biomarker updates to the results initially presented in July 2018 from Study 201 in patients with early Alzheimer’s disease (mild cognitive impairment due to Alzheimer’s disease or mild Alzheimer’s disease dementia). The BAN2401 presentation will be webcast live. To access the live webcasts, please visit the Investors section of Eisai’s website on the day at https://www.eisai.com/ir/index.html.

There will be an oral elenbecestat presentation which will include additional data on the Study 202 results that were initially presented in July 2018 in patients with mild cognitive impairment and mild to moderate Alzheimer’s disease. Elenbecestat is currently being investigated in two ongoing Phase III clinical studies (MISSION AD1/2) in patients with early Alzheimer’s disease.

Meanwhile, for aducanumab, there will be several presentations on late breaking abstracts including the results of analyses of cumulative safety data from the Phase Ib study PRIME long-term extension study of patients with early Alzheimer’s disease initially announced in August 2018. Currently, Eisai and Biogen are advancing two Phase III clinical studies (ENGAGE/EMERGE) on aducanumab.

In addition, there will be a presentation on data from a first-in-kind Phase II clinical study (Study 202) on the investigational sleep-wake regulation agent lemborexant in Alzheimer’s disease patients with irregular sleep-wake rhythm disorder (ISWRD). Discovered by Eisai, lemborexant has been jointly developed with Purdue Pharma L.P. since August 2015.

Eisai is aiming to realize prevention and cure of dementia through a holistic approach to dementia drug discovery research based on a foundation of over 30 years of experience of drug discovery activities in the area of Alzheimer’s disease / dementia. Eisai is striving to create innovative medicines as soon as possible in order to further contribute to addressing the unmet medical needs of, as well as increasing the benefits provided to, patients and their families.