An international group of researchers led by the Peninsula Medical School and the University of Exeter have for the first time identified changes in sex hormones associated with BPA exposure in men, in a large population study. The study results are published in the latest issue of Environmental Health Perspectives.

Researchers analysed data from the InCHIANTI study, an Italian population sample. The team measured the amount of BPA excreted per day in urine samples. 715 adults aged between 20 and 74 years were studied. The study aimed to measure the daily BPA loads excreted by adults, and to examine statistical associations between the amount of BPA exposure and serum oestrogen and testosterone concentrations.

The average BPA daily exposure level in this European study population (over 5 micrograms per day) was slightly higher than recent comparable estimates for the USA population. The study found that higher BPA exposure was statistically associated with endocrine changes in men, specifically small increases in levels of testosterone in the blood.

BPA has a similar molecular structure to oestrogen and does cause some disruption of sex hormone signalling in laboratory animals, but this is the first large human study to suggest that it may have similar effects in adults at ‘background’ exposure levels.